So in the "traditional sense", it's a classic trap game. Inferior opponent sandwiched in between two tough division games, and especially coming off a big, emotional win. Historically, it's the prototype spot for a massive letdown by the superior team. History doesn't necessarily suggest losing it per say, but a much closer game than people expect is certainly possible (also why the sharps are in on Indy this week).
However, also historically, Lamar doesn't really have "trap games". It was an expected thing with Flacco, but not with Lamar.
Since start of 2019, Lamar has lost 15 regular season games. One he was injured early and didn't finish.
Of the other 14, only 3 losses were to teams that didn't make the playoffs that year, and two were teams who finished the year with a weaker record than ours.
So the teams we generally lose to in the Lamar era are effectively "good teams" (playoff teams). We rarely get beat by an inferior opponent when Lamar plays the whole game.