It is nothing but arrogance of the highest order that we humans believe that (now this thing is amongst us, whatever its origin) that we can now meangingfully affect the outcomes. The die are cast. We will now all be exposed, and a percentage of us will not survive it. Apparent co-morbidities include chronic systemic inflammation (therefore hypertension, obesity, type II diabetes, many cancers, etc), and ACEII-inhibitors, HMG-CoA Reductase inhibiters (statins). There is a particular association with age, however this relationship holds for all the comorbidities already listed. "Isolation" only delays the outcome, it doesn't meaningfully moderate it.